HP-β-CD

SKU: orb1306967

Description

(2-Hydroxypropyl)-β-cyclodextrin

Key Properties

• CAS Number: 128446-35-5
• MW: 1541.547
• Purity: ≥98% (May vary between batches)
• Formula: C₆₃H₁₁₂O₄₂
• SMILES: CC(O)COC[C@@H]1O[C@H]2O[C@H]3[C@H](COCC(C)O)O[C@@H](O[C@H]4[C@H](COCC(C)O)O[C@@H](O[C@H]5[C@H](COCC(C)O)O[C@@H](O[C@H]6[C@H](COCC(C)O)O[C@@H](O[C@H]7[C@H](COCC(C)O)O[C@@H](O[C@H]8[C@H](COCC(C)O)O[C@@H](O[C@@H]1[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]8O)[C@@H](O)[C@@H]7O)[C@@H](O)[C@@H]6O)[C@@H](O)[C@@H]5O)[C@@H](O)[C@@H]4O)[C@@H](O)[C@@H]3O
• Target: Others
• Solubility: DMSO:45 mg/mL;10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL;H2O:50 mg/mL

Bioactivity

• Target IC50:
  SKOV3 cells:1.94 μM|leukemia cell:3.86–10.09 mM
• In Vivo:
  Intraperitoneal injection of HP-β-CD significantly improves survival in leukemia mouse models. Systemic administration of HP-β-CD to mice has no significant adverse effects.
• In Vitro:
  Cell treatment with (2-hydroxypropyl)-β-cyclodextrin can activate the activation of the transcription factor EB (the main regulator of lysosomal function and autophagy) and enhance the cell's autophagy clearance ability. HP-β-CD treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for HP-β-CD after 72 hours exposure are in the range of 3.86–10.09 mM. HP-β-CD also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by HP-β-CD.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(2 Hydroxypropyl) β cyclodextrin, (2Hydroxypropyl)βcyclodextrin, HP-b-CD, HP-beta-CD, Inhibitor, Hydroxypropyl-b-cyclodextrin, Hydroxypropyl-beta-cyclodextrin, Hydroxypropyl-β-cyclodextrin, Hydroxypropyl betadex, inhibit

Compound Identifiers

PubChem CID

56972821