Homoharringtonine

SKU: orb1225466

Description

Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myelodysplastic syndrome . Homoharringtonine enhances the paracellular permeability of Caco-2 cell monolayers by modulating the protein expression and localization of claudin isoforms. Homoharringtonine has anti-Y and antileukemic activities, may have the potential ability to treat acute, chronic myeloid leukaemia and Gefitinib-resistant NSCLC.

Key Properties

• CAS Number: 26833-87-4
• MW: 545.61
• Purity: >98% (HPLC)
• Formula: C₂₉H₃₉NO₉
• SMILES: COC1=C[C@@]23[C@H](c4cc(OCO5)c5cc4CCN2CCC3)[C@@H]1OC([C@](O)(CCCC(C)(C)O)CC(OC)=O)=O
• Target: STAT
• Solubility: Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 141633 | Omacetaxine Mepesuccinate

Quick Database Links

Gene Symbol

STAT