Homoeriodictyol

SKU: orb1297338

Description

Homoeriodictyol

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 446-71-9
• MW: 302.28
• Purity: 99.89%
• Formula: C₁₆H₁₄O₆
• SMILES: COc1cc(ccc1O)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1
• Target: Drug Metabolite,5-HT Receptor,transporter,Sodium Channel

Bioactivity

• In Vitro:
  In contrast to other polyphenols, the flavanon Homoeriodictyol promotes glucose uptake by 29.0 ± 3.83% at a concentration of 100 μM. The glucose uptake stimulating effect was sensitive to phloridzin, but not to phloretin, indicating an involvement of the sodium-coupled glucose transporter SGLT-1, but not of sodium-independent glucose transporters (GLUT). In addition, in contrast to the increased extracellular serotonin levels by stimulation with 500 mM D-(+)-glucose, treatment with 100 μM Homoeriodictyol decreased serotonin release by -48.8 ± 7.57% in Caco-2 cells via a phloridzin-sensitive signaling pathway. Extracellular serotonin levels were also reduced by -57.1 ± 5.43% after application of 0.01 μM Homoeriodictyol to human neural SH-SY5Y cells.

Storage & Handling

• Storage: store at low temperature,store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GLUT, flavonoid, Eriocitrin, Inhibitor, Homoeriodictyol, inhibit, metabolite, Drug Metabolite, DrugMetabolite, 5-HT Receptor, 5HTReceptor, 5HT Receptor, SodiumChannel, Sodium Channel

Compound Identifiers

PubChem CID

73635