Homo-PROTAC pVHL30 degrader 1

SKU: orb1308807

Description

Homo-PROTAC pVHL30 degrader 1 is a potent, heterobifunctional small molecule that selectively targets pVHL30 for proteasomal degradation. This tool compound enables the study of VHL biology and PROTAC mechanisms in both cellular and in vivo models for cancer and disease research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2244684-49-7
• MW: 1179.45
• Purity: 98.95% (May vary between batches)
• Formula: C₅₈H₈₂N₈O₁₄S₂
• SMILES: C([C@@H](NC(COCCOCCOCCOCCOCCOCC(N[C@H](C(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)[C@@](C)(C)C)=O)=O)[C@@](C)(C)C)(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4
• Target: PROTACs
• Solubility: DMSO:150 mg/mL (127.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (3.39 mM)

Bioactivity

• In Vitro:
  Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces rapid, potent, and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, HomoPROTAC pVHL30 degrader 1, Homo-PROTAC pVHL30 degrader 1, Homo-PROTAC pVHL-30 degrader 1, Homo PROTAC pVHL30 degrader 1, Inhibitor, PROTACs, VHL

Compound Identifiers

PubChem CID

134160242