Homo-PROTAC cereblon degrader 1

SKU: orb1308808

Description

Homo-PROTAC cereblon degrader 1

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2244520-98-5
• MW: 660.63
• Purity: 98.30% (May vary between batches)
• Formula: C₃₂H₃₂N₆O₁₀
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCNC4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4
• Target: PROTACs,IKZF
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.57 mM);DMSO:200 mg/mL (302.74 mM)

Bioactivity

• In Vitro:
  Homo-PROTAC cereblon degrader 1 (0-1 μM, 16 hours) effectively reduces Cereblon protein levels in the multiple myeloma cell line NCI-H929. Experimental results indicate that the effect is observed at a concentration of 10 nM after 16-hour incubation. The degradation efficiency reaches its peak at concentrations between 100 nM and 1 μM. However, when the concentration is further increased to 100 μM, the degradation of Cereblon is completely inhibited . When MM1S cells were treated with Homo-PROTAC cereblon degrader 1 (100 nM, 0-24 hours), cereblon protein levels decreased within 15 minutes and peaked at 6 hours . The effects of homo-PROTAC cerebrone degrader 1 (0-10 μM, 4 days) on the proliferation of palomidomide-sensitive multiple myeloma cell lines MM1S, NCI-H929, LP-1, KMS27, and RPMI 8226 were investigated. The results showed that Homo-PROTAC cereblon degrader 1 had little effect on the proliferation of the cells at concentrations of ≤1 μM .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cereblon, Inhibitor, Homo PROTAC cereblon degrader 1, HomoPROTAC cereblon degrader 1, Homo-PROTAC cereblon degrader 1, inhibit, PROTACs

Compound Identifiers

PubChem CID

137628659