Homer

SKU: orb2695197

Description

Homer is a potent and selective WDR5 degrader with a DC50 of 53 nM in MV4-11 cells, acting post-translationally without affecting WDR5 mRNA. This probe is a valuable chemical tool for investigating WDR5 function in chromatin regulation and leukemia models, both in vitro and in vivo.

Research Area

Cell Biology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• Target: PROTACs,DNA/RNA Synthesis
• Molecular Weight: 1012.15
• CAS Number: 2737222-94-3
• Formula: C₅₂H₆₀F₃N₉O₇S
• SMILES: N(C(=O)C=1C(C(F)(F)F)=CC(=O)NC1)C2=C(C=CC(=C2)C3=CC=C(C(NCCCCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)C=C3)N7CCN(C)CC7

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

157049306