HODHBt

SKU: orb1219345

Description

HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.

Key Properties

• CAS Number: 28230-32-2
• MW: 163.14
• Purity: >98% (HPLC)
• Formula: C₇H₅N₃O₂
• SMILES: C1=CC=C2C(=C1)C(=O)N(N=N2)O
• Target: STAT
• Solubility: DMSO:Soluble

Bioactivity

• In Vitro:
  HODHBt (100 μM; 24 h, and 48 h respectively) increases IL-15-mediated STAT phosphorylation in NK cells and enhances the cytotoxic profile of NK cells. HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL) cytotoxicity of NK cells against HIV-infected cells (K562 cells). HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL, 6 h) cytotoxicity of NK cells against cancer cell lines (A2780 and U877; OCILy1 and OCILy10). HODHBt (100 μM; 7 d) results in enhanced memory response upon recall in generation of human CIML NK cells in vitro.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STAT