HNHA

SKU: orb1306191

Description

HNHA

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 926908-04-5
• MW: 303.42
• Purity: 98.04% (May vary between batches)
• Formula: C₁₇H₂₁NO₂S
• SMILES: ONC(=O)CCCCCCSc1ccc2ccccc2c1
• Target: HDAC
• Solubility: DMSO:15 mg/mL (49.44 mM);Ethanol:15 mg/mL (49.44 mM)

Bioactivity

• Target IC50:
  HDAC:100 nM
• In Vivo:
  Several HDAC inhibitors, including MS-27-275 and a hydroxyamide-based HDAC inhibitors such as SAHA have been investigated extensively and shown to inhibit tumor growth in vivo.
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• In Vitro:
  Treatment of cells with HNHA could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of HT1080 cell invasion. HNHA was able to inhibit in-vitro HDAC enzyme activity as well as proliferation of human fibrosarcoma cells (HT1080).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FM3A cells, Inhibitor, Hypoxia-inducible factors, HDAC, Matrix metalloproteinases, MCF-7 cells, HNHA, HIF-PH, HIFs, HIF/HIF Prolyl-Hydroxylase, Histone deacetylases, inhibit, MMP, Anti-cancer activity, Breast cancer

Compound Identifiers

PubChem CID

16126782