HLCL-61 hydrochloride

SKU: orb1300402

Description

HLCL-61 hydrochloride is a selective PRMT5 inhibitor used in research for acute myeloid leukemia (AML). It has demonstrated activity in both cellular assays and animal models, making it a valuable tool for investigating PRMT5's role in hematological malignancies and epigenetic therapy.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 1158279-20-9
• MW: 380.91
• Purity: >99.99% (May vary between batches)
• Formula: C₂₃H₂₄N₂O·ClH
• SMILES: Cl.CCn1c2ccccc2c2cc(CNCc3ccccc3OC)ccc12
• Target: Apoptosis,Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.25 mM);Ethanol:15 mg/mL (39.38 mM);DMSO:50 mg/mL (131.26 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  PRMT5:16.74 μM
• In Vitro:
  HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.
• Cell Research:
  CD11b expression is tested by flow cytometry on cells treated with DMSO or HLCL-61 (25 and 50 μM) for 48 h.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HLCL 61, HLCL-61, HLCL-61 HCL, HLCL-61 Hydrochloride, HistoneMethyltransferase, Histone Methyltransferase, Apoptosis, PRMT5

Compound Identifiers

PubChem CID

17208222