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HL-8

SKU: orb1983087

Description

HL-8 is a potent PROTAC that induces complete degradation of PI3K at 10 µM within 8 hours. This mechanism demonstrates utility for probing PI3K-dependent signaling pathways in cancer research, supporting both in vitro cellular studies and in vivo preclinical investigations.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number2766352-64-9
MW1144.27
FormulaC57H59F2N11O9S2
SMILESCOc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(-c3nnc(o3)-c3ccccc3C(=O)NCCCCCCC(=O)N[C@H](C(=O)N3C[C@@H](O)C[C@@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(C)(C)C)n2c1
TargetOthers,PI3K

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information