HK2-IN-4

SKU: orb3210961

Description

HK2-IN-4 is a selective hexokinase 2 (HK2) inhibitor with an IC50 value of 0.79 μM and a Kd value of 0.41 μM. It disrupts the interaction between HK2 and the voltage-dependent anion channel 1 (VDAC1). HK2-IN-4 reduces lactate and ATP levels in cancer cells and induces apoptosis markers, including increased p-AMPK/AMPK ratio and Bax levels, along with decreased Bcl2 levels. Additionally, HK2-IN-4 inhibits the proliferation of cancer cells with high HK2 expression and can be utilized in research related to colorectal cancer and non-small cell lung cancer.

Key Properties

• CAS Number: 2748366-80-3
• MW: 391.46
• Formula: C₂₄H₂₅NO₄
• SMILES: O=C(OC1C=CC23C4=C(OC2C1)C(OC)=CC=C4CN(C)CC3)C=5C=CC=CC5
• Target: AMPK,Bcl-2 Family,VDAC,Hexokinase,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AMPK,Bcl-2 Family,VDAC,Hexokinase,Apoptosis