HJC0152

SKU: orb1226321

Description

A potent, orally bioavailable STAT3 signaling inhibitor that exhibits promising antitumor effects in vitro and in vivo via inactivating STAT3 and downstream miR-21/β-catenin axis; potently inhibits MCF-7, MDA-MB-231, AsPC1 and Panc-1a cell with IC50 of 0.91, 1.64, 1.9 and 1.08 uM, respectively; suppresses HNSCC cell proliferation, arrests the cell cycle at the G0-G1 phase, induces apoptosis and reduces cell invasion in both SCC25 and CAL27 cell lines; inhibits nuclear translocation of phosphorylated STAT3 at Tyr705 and decreases VHL/β-catenin signaling activity via regulation of miR-21; suppresses MDA-MB-231 xenograft tumor growth in vivo.

Key Properties

• CAS Number: 1420290-99-8
• MW: 406.644
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₄Cl₃N₃O₄
• SMILES: O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2OCCN.[H]Cl
• Target: STAT
• Solubility: DMSO: 82 mg/mL (201.7 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HJC-0152 | HJC 0152

Quick Database Links

Gene Symbol

STAT