HIV-1 Nef-IN-1

SKU: orb1298422

Description

HIV-1 Nef-IN-1 is a small molecule inhibitor that disrupts the HIV-1 Nef-SH3Hck protein-protein interaction with a Kd of 6.7 µM. This compound serves as a valuable research tool for studying Nef-mediated pathogenesis in vitro, including mechanisms of immune evasion and viral replication in cellular models.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 13728-56-8
• MW: 264.32
• Purity: 99.90% (May vary between batches)
• Formula: C₁₈H₁₆O₂
• SMILES: OC(=O)CCCc1ccc2ccc3ccccc3c2c1
• Target: HIV Protease
• Solubility: DMSO:50 mg/mL (189.16 mM)

Bioactivity

• Target IC50:
  HIV-1 (Nef):6.7 μM (Kd)
• In Vitro:
  HIV-1 Nef-IN-1 inhibits cell viability of COS7 cells, and the cell inhibition rate is 63.2%

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiviral, inhibit, Nef, Human immunodeficiency virus, HIV, HIVProtease, HIV Protease, HIV 1 Nef IN 1, HIV-1 Nef, HIV1 NefIN1, HIV-1 Nef-IN-1, HIV-1, Inhibitor, PPI, SH3

Compound Identifiers

PubChem CID

96904