HIV-1 inhibitor-54

SKU: orb1745222

Description

HIV-1 inhibitor-54 is a potent small molecule antiviral agent with an EC50 of 32 nM against wild-type HIV-1 (IIIB) in MT-4 cell assays. This compound is a useful research tool for studying HIV-1 replication mechanisms and for in vitro antiviral screening in relevant cell culture models.

Research Area

Infectious Disease & Virology, Infectious Disease & Virology; Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 2771211-71-1
• MW: 534.63
• Purity: 99.44% (May vary between batches)
• Formula: C₂₇H₃₀N₆O₄S
• SMILES: C(=O)(C1=CC=2C(N1)=CC=C(NS(C)(=O)=O)C2)N3CCC(NC=4N=C(OC5=C(C)C=CC=C5C)C=CN4)CC3
• Target: HIV Protease
• Solubility: DMSO:Slightly soluble

Bioactivity

• Target IC50:
  HIV-1 (wild-type):12 μM|HIV-1 (WT):0.032 μM(EC50)|Y181C:0.84 μM(EC50)|Y188L:0.67 μM(EC50)|L100I:3.3 μM(EC50)|HIV-1 (F227L+V106A):2.7 μM(EC50)|E138K:0.080 μM(EC50)|K103N:0.52 μM(EC50)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HIVProtease, HIV1inhibitor54, HIV-1 inhibitor-54, HIV-1, HIV Protease

Compound Identifiers

PubChem CID

166642647