Histrelin

SKU: orb1217666

Description

Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency. It is considered a GnRH agonist. Histrelin is used in the treatment of hormone-sensitive cancers of the prostate in men and uterine fibroids in women.

Key Properties

• CAS Number: 76712-82-8
• MW: 1323.5
• Purity: >98% (HPLC)
• Formula: C₆₆H₈₆N₁₈O₁₂
• SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
• Target: Others
• Solubility: DMSO:Soluble; Water:Insoluble

Bioactivity

• In Vivo:
  Animal model: Csfmop/Csfmop mice. Dosage: 0.001, 0.05, and 0.1 mg/kg. Administration: Subcutaneous injection. Result: Increased serum FSH concentrations by 4-fold. Animal model: Rabbits. Dosage: 10, 30, or 100 μg /day. Administration: Subcutaneous injection for 4 weeks. Result: Caused a regression of the endometrial glands and a thinning of the stroma.
• In Vitro:
  Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants. Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Supprelin LA

Quick Database Links

Gene Symbol

Others