Hispidin

SKU: orb1299502

Description

Hispidin is a naturally occurring polyphenol with documented antioxidant, anti-inflammatory, and cytoprotective activities. It is utilized in research areas such as neuroprotection and oxidative stress, with studies conducted in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 555-55-5
• MW: 246.22
• Purity: 99.55% (May vary between batches)
• Formula: C₁₃H₁₀O₅
• SMILES: Oc1cc(=O)cc(\C=C\c2ccc(O)c(O)c2)o1
• Target: p38 MAPK,Akt,Endogenous Metabolite,GSK-3,ROS,ERK,JAK,STAT,JNK,Nrf2,Ferroptosis,PKC
• Solubility: DMSO:22.5 mg/mL (91.38 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.06 mM)

Bioactivity

• In Vitro:
  Hispidin from P. linteus exhibited quenching effects against DPPH radicals, superoxide radicals, and hydrogen peroxide in a dose-dependent manner. Intracellular reactive oxygen species scavenging activity of hispidin was approximately 55% at a concentration of 30 μM. In addition, hispidin was shown to inhibit hydrogen peroxide-induced apoptosis and increased insulin secretion in hydrogen peroxide-treated cells. These combined results indicate that hispidin may act as an antidiabetic and that this property occurs through preventing β-cells from the toxic action of reactive oxygen species in diabetes.Hispidin inhibits protein kinase C β (PKCβ ; IC50 = 2 μM) with no activity against alkaline phosphatase
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-diabetic, anti-dementia, anti-cancer, anti-oxidant, Endogenous Metabolite, fungal, EndogenousMetabolite, Inhibitor, Hispidin, inhibit, metabolite, PKC, PKCβ, properties, Protein kinase C

Compound Identifiers

PubChem CID

54685921