Hirsuteine

SKU: orb1297565

Description

Hirsuteine is a natural alkaloid that acts as a non-competitive antagonist of nicotinic acetylcholine receptors, inhibiting ion channel function and blocking nicotine-evoked dopamine release. It is used in neuroscience research to study addiction mechanisms and receptor pharmacology in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 35467-43-7
• MW: 366.45
• Purity: 99.83%
• Formula: C₂₂H₂₆N₂O₃
• SMILES: [H][C@]12C[C@@H]([C@H](CN1CCc1c2[nH]c2ccccc12)C=C)C(=C/OC)\C(=O)OC
• Target: Dopamine Receptor,AChR
• Solubility: DMSO:55 mg/mL (150.09 mM)

Bioactivity

• In Vitro:
  Hirsuteine (300 nM-10 microM) inhibited dopamine release evoked by 100 microM nicotine in a concentration-dependent manner. Hirsuteine did not produce a parallel shift of the concentration-response relationship curve for nicotine, but reduced maximal dopamine release. Dopamine release evoked by 60 and 155 mM KCl was also inhibited by Hirsuteine, but the concentration necessary for significant inhibition was higher (more than 10 microM). Under whole cell voltage-clamp, Hirsuteine reversibly inhibited inward currents activated by 100 microM nicotine. The current inhibition was slightly accelerated by hyperpolarization

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dopamine, Dopamine Receptor, DopamineReceptor, Inhibitor, Hirsuteine, inhibit

Compound Identifiers

PubChem CID

3037151