Hinokiflavone

SKU: orb1302366

Description

Hinokiflavone is a bifunctional small molecule that inhibits pre-mRNA splicing by blocking spliceosomal B complex assembly and acts as a SENP1 SUMO protease inhibitor. Its cytotoxicity and MMP-9 inhibitory activity make it a useful research tool for studying splicing regulation, SUMOylation, and cancer cell biology in vitro.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 19202-36-9
• MW: 538.46
• Purity: 98.67% (May vary between batches)
• Formula: C₃₀H₁₈O₁₀
• SMILES: Oc1ccc(cc1)-c1cc(=O)c2c(O)c(Oc3ccc(cc3)-c3cc(=O)c4c(O)cc(O)cc4o3)c(O)cc2o1
• Target: Protease,MMP,Apoptosis,Bcl-2 Family,E1/E2/E3 Enzyme
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (1.86 mM);DMSO:55.56 mg/mL (103.18 mM)

Bioactivity

• In Vitro:
  Hinokiflavone exhibited a time- and dose-dependent manner apoptosis induction by upregulating expression of Bax and downregulating Bcl-2 in breast cancer cells. Furthermore, hinokiflavone significantly inhibited the migration and invasion of breast cancer cells by impairing the process of epithelial-to-mesenchymal transition. The tumour growth was distinctly inhibited by treatment of hinokiflavone in a xenograft tumour mouse model of MDA-MB-231 cells. Immunohistochemical analysis of tumour sections showed that MMP-2+ cells and Ki-67+ cells were remarkably decreased in tumour tissues of mice after treatment of hinokiflavone, indicating that hinokiflavone inhibits not only proliferation but also metastasis of breast cancer cells.Hinokiflavone can be a potential drug to breast cancer.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

bcL-2, bax, E3Enzyme, E3 ligating enzyme, E3 Enzyme, E2Enzyme, E2 conjugating enzyme, E2 Enzyme, E1 activating enzyme, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, MMP, inhibit, Hinokiflavone, Inhibitor, Ubiquitin activating enzyme, Ubiquitin ligase, Ubiquitin conjugating enzyme

Compound Identifiers

PubChem CID

5281627