HIF-2α-IN-4

SKU: orb1302183

Description

HIF-2α-IN-4 is a potent small molecule inhibitor of HIF-2α protein synthesis, with an IC50 of 5 µM, targeting the 5'UTR iron response element for oxygen sensing. It effectively suppresses both constitutive and hypoxia-induced HIF-2α expression, making it a valuable tool for studying HIF-2α biology in cancer and renal disease models in vitro.

Research Area

Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 882268-69-1
• MW: 287.32
• Purity: ≥98% (May vary between batches)
• Formula: C₉H₉N₃O₄S₂
• SMILES: COC(=O)c1sccc1N\N=C(/C#N)S(C)(=O)=O
• Target: HIF/HIF Prolyl-Hydroxylase
• Solubility: DMSO:16.67 mg/mL (58.02 mM)

Bioactivity

• Target IC50:
  HIF2α:5 μM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

iron-responsive, inhibit, oxygen sensing, HIF, HIF 2α IN 4, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, HIF-2a-IN-4, HIF-2α, HIF2αIN4, HIF-2α-IN-4, HIF-2alpha-IN-4, HIF-PH, HIFProlylHydroxylase, HIFs, Inhibitor, hypoxia, Hypoxia-inducible factors, translation

Compound Identifiers

PubChem CID

6375097