HIF-2α-IN-17

SKU: orb3210361

Description

HIF-2α-IN-17 is a selective inhibitor of hypoxia-inducible factor 2 alpha (HIF2α) that binds to the PAS-B domain of HIF2α. It disrupts the interaction between HIF2α and the molecular chaperone Hsp70, leading to the proteasomal degradation of HIF2α. HIF-2α-IN-17 exhibits antitumor activity by inducing apoptosis in cancer cells and can be utilized in research on cancers such as clear cell renal carcinoma.

Key Properties

• CAS Number: 861212-49-9
• MW: 311.31
• Formula: C₁₇H₁₄FN₃O₂
• SMILES: O=C(N=C1C=2C=CC=CC2NC(=O)N1CC)C3=CC=C(F)C=C3
• Target: HSP,HIF/HIF Prolyl-Hydroxylase,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HSP,HIF/HIF Prolyl-Hydroxylase,Apoptosis,Caspase