Hibifolin

SKU: orb1297340

Description

Hibifolin is a flavonol glycoside that acts as an adenosine deaminase inhibitor (Ki = 49.92 µM). It has demonstrated neuroprotective effects against beta-amyloid-induced toxicity in cellular models, supporting its research application in neuroscience and Alzheimer's disease studies.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 55366-56-8
• MW: 494.36
• Purity: 98.92% (May vary between batches)
• Formula: C₂₁H₁₈O₁₄
• SMILES: O[C@H]1[C@H](Oc2c(O)cc(O)c3c2oc(-c2ccc(O)c(O)c2)c(O)c3=O)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O
• Target: Caspase,Antibacterial,Adenosine Deaminase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.05 mM);DMSO:55 mg/mL (111.25 mM)

Bioactivity

• Target IC50:
  ADA:49.92 μM (Ki)
• In Vitro:
  the inhibitory activity of a plant flavonoid, hibifolin on ADA is investigated using enzyme kinetic assay and isothermal titration calorimetry. The inhibitory constant of hibifolin was found to be 49.92μM 3.98 and the mode of binding was reversible. Isothermal titration calorimetry showed that the compound binds ADA with binding energy of -7.21Kcal/mol. The in silico modeling and docking studies showed that the bound ligand is stabilized by hydrogen bonds with active site residues of the enzyme. hibifolin can act as a potential inhibitor of ADA.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-inflammatory, anti-proliferative, Adenosinedeaminase, Adenosine Deaminase, Adenosine deaminase, adenosine, inhibit, neurotoxicity, Inhibitor, Hibifolin, deaminase

Compound Identifiers

PubChem CID

5490334