HHS-0701

SKU: orb1685584

Description

HHS-0701 is a sulfur-triazole exchange (SuTEx) compound that acts as a potent and selective inhibitor of prostaglandin reductase 2 (PTGR2). It effectively blocks the enzymatic conversion of 15-keto-PGE2, making it a valuable chemical probe for studying lipid metabolism in both cellular and biochemical assays.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2851993-91-2
• MW: 396.46
• Purity: 97.24% (May vary between batches)
• Formula: C₂₀H₂₀N₄O₃S
• SMILES: S(=O)(=O)(C1=CC=C(C(=O)N2CCC(CC2)C3=CC=CC=C3)C=C1)N4C=NC=N4
• Target: Prostaglandin Receptor,Others
• Solubility: DMSO:3.97 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.52 mM)

Bioactivity

• In Vitro:
  HHS-0701 (0.1, 0.25, 0.5, 1, 2.5, 5, 10, 25 μM; 2 hours) caused a concentration-dependent blockade of probe labeling in recombinant PTGR2 overexpressing HEK293T cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HHS 0701, HHS0701, HHS-0701, PTGR2

Compound Identifiers

PubChem CID

155925911