HH-2853

SKU: orb2815682

Description

HH-2853 is a potent and selective dual EZH1/2 inhibitor with low nM IC50 values. It effectively reduces H3K27 methylation in cells and shows superior in vivo antitumor efficacy compared to tazemetostat in xenograft models with EZH2 mutations or SWI/SNF alterations, making it a valuable research tool for epigenetics and oncology studies.

Key Properties

• CAS Number: 2202678-04-2
• MW: 611.66
• Formula: C₃₁H₃₆F₃N₇O₃
• SMILES: O=C(NCC=1C(=O)NC(=CC1OC)C)C2=CC3=C(C=CN3C(=C2C)C(N4CCN(CC4)CC(F)(F)F)C)C5=NN=C(C=C5)C

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138733517