HG6-64-1

SKU: orb1707214

Description

HG6-64-1 (HMSL 10017-101-1) is a selective B-Raf V600E inhibitor, demonstrating potent activity with an IC50 of 90 nM in cellular assays. This compound is a valuable chemical probe for investigating MAPK/ERK pathway signaling in cancer research, applicable in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1315329-43-1
• MW: 577.64
• Purity: 99.89% (May vary between batches)
• Formula: C₃₂H₃₄F₃N₅O₂
• SMILES: O(C)C1=C2C(=NC=C1/C=C/C3=CC(C(NC4=CC(C(F)(F)F)=C(CN5CCN(CC)CC5)C=C4)=O)=CC=C3C)NC=C2
• Target: Raf
• Solubility: DMSO:40 mg/mL (69.25 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (4.33 mM)

Bioactivity

• Target IC50:
  B-Raf (V600E, Ba/F3 cells):0.09 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HMSL 10017-101-1, HG6 64 1, HG6641, HG-6-64-1, HG6-64-1, B-RafV600E

Compound Identifiers

PubChem CID

53302361