HG-10-102-01

SKU: orb1299989

Description

HG-10-102-01 is a potent and selective small molecule inhibitor of LRRK2 kinase, demonstrating an IC50 of 20.3 nM. This compound is a valuable research tool for investigating LRRK2's role in Parkinson's disease pathogenesis, enabling both in vitro biochemical assays and in vivo disease model studies.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1351758-81-0
• MW: 377.83
• Purity: 99.73% (May vary between batches)
• Formula: C₁₇H₂₀ClN₅O₃
• SMILES: CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Cl
• Target: MNK,LRRK2
• Solubility: DMSO:50 mg/mL (132.33 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.29 mM)

Bioactivity

• In Vivo:
  HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BBB, HEK293 cells, Inhibitor, HG1010201, HG-10-102-01, HG 10 102 01, MAPK interacting kinase, MAP kinase interacting kinase, Leucine-rich repeat kinase 2, Mouse embryonic fibroblast cells, Mouse Swiss 3T3 cells, inhibit, LRRK2, Parkinson's disease, Mitogen activated protein kinase interacting kinase, MNK, Radiosynthesis, Positron emission tomography, PET, Ser910, Ser935

Compound Identifiers

PubChem CID

58539301