Hexylresorcinol

SKU: orb1226432

Description

Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase, causing 90% loss of activity at 100 μM.(In Vitro):Hexylresorcinol potently inhibits Gram positive bacteria, with MICs of 20-50 mg/L for several Gram positive bacteria. Gram negative bacteria, yeasts and fungi are less sensitive to it.Hexylresorcinol inhibits oxidative DNA damage in human lymphocytes by increasing levels of glutathione and modulation of antioxidant enzymes (GPX, GR and GST).Hexylresorcinol (1-10 μg/mL; 24-72 hours) suppresses squamous carcinoma cell line SCC-9 proliferation.Hexylresorcinol has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis.Hexylresorcinol upregulates TGF-β/SMAD/VEGF signaling in endothelial cells and induces vascular regeneration and remodeling for wound healing.(In Vivo):Hexylresorcinol (10 mg/kg; i.p.; daily; for 16 days) inhibits tumor cell proliferation in mouse tumor xenografts and concomitant application of calcium channel blocker partly reverses the antitumor effect of Hexylresorcinol.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 136-77-6
• MW: 194.27
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₈O₂
• SMILES: OC1=CC=C(CCCCCC)C(O)=C1
• Target: Tyrosinase
• Solubility: Water: 500 mg/L at 18 °C.

Bioactivity

• In Vivo:
  Hexylresorcinol (10 mg/kg; i.p.; daily; for 16 days) inhibits tumor cell proliferation in mouse tumor xenografts and concomitant application of calcium channel blocker partly reverses the antitumor effect of Hexylresorcinol. Animal model: Male nude mice (BALB/cAnNCrj-nu/nu), with SCC-9 cells xenograft. Dosage: 10 mg/kg. Administration: Intraperitoneal injection, daily, for 16 days. Result: Reduced tumor formation In vivo.
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• In Vitro:
  Hexylresorcinol potently inhibits Gram positive bacteria, with MICs of 20-50 mg/L for several Gram positive bacteria. Gram negative bacteria, yeasts and fungi are less sensitive to it. Hexylresorcinol inhibits oxidative DNA damage in human lymphocytes by increasing levels of glutathione and modulation of antioxidant enzymes (GPX, GR and GST). Hexylresorcinol (1-10 μg/mL; 24-72 hours) suppresses squamous carcinoma cell line SCC-9 proliferation. Hexylresorcinol has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis. Hexylresorcinol upregulates TGF-β/SMAD/VEGF signaling in endothelial cells and induces vascular regeneration and remodeling for wound healing. Cell Proliferation Assay Cell line: SCC-9 cells. Concentration: 1 μg/mL, 5 μg/mL, 10 μg/mL. Incubation time: 24 hours, 48 hours, 72 hours. Result: Inhibited SCC-9 cells proliferation. Apoptosis Analysis Cell line: SCC-9 cells. Concentration: 10 μg/mL. Incubation time: 24 hours. Result: Induced morphological and biochemical changes in SCC-9 cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hexylresorcinol | Ascaricid | Ascarinol | Ascaryl | NSC 1570

Quick Database Links

Gene Symbol

Tyrosinase