Hexestrol

SKU: orb1221738

Description

Hexestrol is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation.(In Vivo):Hexestrol (3 and 6 mg/kg; i.p. once daily for 30 days) has a not significant influence in the ovaries from mice at the dose of 3 mg/kg.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 84-16-2
• MW: 270.37
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₂O₂
• SMILES: CC[C@@H]([C@@H](CC)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
• Target: Glucokinase
• Solubility: In Vitro: DMSO : 100 mg/mL (369.86 mM)

Bioactivity

• In Vivo:
  Hexestrol (3 and 6 mg/kg; i.p. once daily for 30 days) has a not significant influence in the ovaries from mice at the dose of 3 mg/kg. Animal model: Mus musculus (90-120 days, 25-50 g). Dosage: 3, 6 mg/kg (adopted the same dose used to increase weight gain in cattle). Administration: i.p. once daily for 30 days. Result: Numerous follicles in different stages of development were found at the dose of 3 mg/kg in the ovaries. Not detected the corpora lutea (CL) at the dose of 6 mg/kg.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cycloestrol | Erythrohexestrol | Hexoestrol | HSDB 2149

Quick Database Links

Gene Symbol

Glucokinase