Hexadimethrine bromide

SKU: orb1308809

Description

Hexadimethrine bromide (Polybrene) is a cationic polymer widely used to enhance viral transduction efficiency in both in vitro and in vivo gene delivery research. It facilitates retroviral and lentiviral gene transfer by neutralizing charge repulsion between viral particles and cell membranes.

Key Properties

• CAS Number: 28728-55-4
• MW: 404.275
• Purity: 99.54% (May vary between batches)
• Formula: (C₁₃H₃₀N₂)n.Br₂
• SMILES: [Br-].[Br-].CCCCCCC[N+](C)(C)CCC[N+](C)(C)C
• Target: Others
• Solubility: DMSO:4.5 mg/mL;H2O:125 mg/mL

Bioactivity

• In Vitro:
  Hexadimethrine bromide impedes the proliferation of human mesenchymal stem cells during lentiviral transduction and is deemed non-toxic at low concentrations. Yet, at levels exceeding 10 µg/mL, it adversely impacts the proliferation of certain cell types. Moreover, cells treated with Hexadimethrine bromide and then trypsinized appear significantly enlarged under microscopic examination.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide, inhibit, Inhibitor, heparin, Hexadimethrine, Hexadimethrine bromide, Hexadimethrine Bromide, Polybrene

Compound Identifiers

PubChem CID

24769