Hexaconazole

SKU: orb1301379

Description

Hexaconazole is a triazole fungicide that inhibits fungal cytochrome P450 14α-demethylase, disrupting ergosterol synthesis and membrane integrity. It is used in agricultural research and in vitro studies to investigate antifungal mechanisms and resistance.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 79983-71-4
• MW: 314.21
• Purity: 98.00% (May vary between batches)
• Formula: C₁₄H₁₇Cl₂N₃O
• SMILES: CCCCC(O)(Cn1cncn1)c1ccc(Cl)cc1Cl
• Target: Antifungal,Reactive Oxygen Species,ROS
• Solubility: DMSO:55 mg/mL (175.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.37 mM)

Bioactivity

• In Vitro:
  Hexaconazole is fungicidal against the powdery mildews B. graminis and S. cucurbitae on cucumber plants in a concentration-dependent manner and is curative against powdery mildew on barley plants when used at a concentration of 6.7 mg/L.It also inhibits growth of R. bataticola and S. rolfsii (ED50s = 6.35 and 1.27 mg/L, respectively).
• Cell Research:
  The medium was poured into a set of two petriplates under aseptic conditions in a laminar flow hood. When the medium in the plates was solidified, a mycelial disc of 0.5 cm diameter of freshly grown test fungi taken from periphery was inoculated upside down at the center of the plates. These treated petri dishes were incubated at 28℃ until fungal growth in the control plates was almost complete. Hexaconazole used as commercial fungicide and acetone served as control. All the compounds were tested in triplicates. The mycelia growth of fungi (mm) in both treated (T) and control (C) petri plates was measured diametrically in three different directions and growth inhibition (I) and corrected inhibition (IC) were calculated by using Abbott s formula

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(-)-Hexaconazol, Antifungal, Fungal, Inhibitor, Hexaconazol, Hexaconazole, inhibit, ReactiveOxygenSpecies, Reactive Oxygen Species

Compound Identifiers

PubChem CID

66461