HET0016

SKU: orb1309579

Description

HET0016 is a potent and selective inhibitor of 20-HETE synthase (CYP4A isoforms) and exhibits anti-angiogenic and anti-tumor properties. It is widely used in research exploring cardiovascular disease, cancer biology, and renal physiology in both in vitro and in vivo models.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 339068-25-6
• MW: 206.3
• Purity: >98%
• Formula: C₁₂H₁₈N₂O
• SMILES: CCCCc1ccc(N=CNO)c(C)c1
• Target: Cytochrome/MDR
• Solubility: Soluble in DMSO (20 mg/ml)

Bioactivity

• Target IC50:
  CYP4A1:17.7 nM |CYP4A3: 20.6 nM |CYP4A2: 12.1 nM
• In Vivo:
  HET0016 decreases expression of pro-inflammatory and growth factors and granulocytic MDSCs population in lung microenvironment. HET0016 protects BBB dysfunction after I/R by regulating the expression of MMP-9 and tight junction proteins.HET0016 (10 mg/kg/day; i.v.; for 3 weeks) reduces tumor volume and lung metastasis in an immunocompetent breast cancer mouse model. HET0016 reduces the metalloproteinases' levels in the lungs via PI3K/AKT pathway in mice.
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• In Vitro:
  HET0016 (100 μM; 24 hours, 48 hours) decreases migration and invasion of breast cancer metastatic cells .HET0016 is a selective, non-competitive and irreversible inhibitor of CYP4A .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP4A1, CYP4A2, CYP4A3, HET 0016, HET0016, HET-0016

Compound Identifiers

PubChem CID

2727594