Hesperin

SKU: orb1707218

Description

Hesperidin (6-MSITC), a citrus flavonoid, functions as a circadian decapping enzyme modulator in plants. In research, it demonstrates inhibitory effects on lipid accumulation in 3T3-L1 adipocytes and reduces reactive oxygen and nitrogen species production in RAW264.7 macrophage cells.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 4430-35-7
• MW: 205.34
• Purity: 98.00%
• Formula: C₈H₁₅NOS₂
• SMILES: O=S(C)CCCCCCN=C=S
• Target: Nrf2,ROS
• Solubility: DMSO:25 mg/mL (121.75 mM)

Bioactivity

• In Vivo:
  b>METHODS: Wild-type and Nrf2-deficient mice were fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus hesperin (10 mg/kg, ip, daily), 4) HFD for 6 weeks followed by HFD supplemented with iron for 6 weeks (HFD/iron), and 5) HFD/iron plus hesperin; to investigate whether hesperin could improve hepatic steatosis and iron accumulation. RESULTS: HFD increased hepatic triglycerides in both genotypes and Hesperi; hesperin suppressed the increase in hepatic triglycerides in wild-type mice but did not reduce triglycerides in Nrf2-deficient mice; hesperin did not block hepatic iron accumulation in either genotype.
• In Vitro:
  b>METHODS: HUVEC cells were stimulated with TNF-a or thrombin in the presence of Hesperin (0.03, 0.1, 0.3, 1 µg/ml, 4 hours). The effect of Hesperin on VWF release induced by TNF-a and thrombin was studied. RESULTS: Hesperin slightly increased TNF-a-induced TF activity, but at 1 lg/mL (4.88 μM), Hesperin reduced TNF-a- or thrombin-induced TF activity; Hesperin did not change the TF activity of unstimulated HUVECs; indicating that TF activity is inversely proportional to the concentration of Hesperin.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hesperin, Nrf2, 6MSITC, 6-MSITC, 6 MSITC, ros

Compound Identifiers

PubChem CID

9815648