Hesperadin

SKU: orb1300686

Description

Hesperadin

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology

Key Properties

• CAS Number: 422513-13-1
• MW: 516.65
• Purity: 98.04%
• Formula: C₂₉H₃₂N₄O₃S
• SMILES: CCS(=O)(=O)Nc1ccc2NC(=O)\C(=C(/Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)c2c1
• Target: Aurora Kinase,Influenza Virus,Parasite,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.87 mM);DMSO:55.3 mg/mL (107.04 mM);Ethanol:27.7 mg/mL (53.61 mM)

Bioactivity

• Target IC50:
  Aurora B:250 nM
• In Vitro:
  In HeLa cells, Hesperadin causing defects in mitosis and cytoplasmic division, leading to cell proliferation and polyploidization stopped, because of Aurora B function Inhibition during chromosome connection. Addition of 20-100 nM Hesperadin leading to loss of phosphorylation o the mitogenic histone H3 a the Ser10 site. When Hesperadin concentration was 1 μM, Other kinases (AMPK, Lck, MKK1, MAPKAP-K1, CHK1, and PHK) activity were significantly reduced.In an in vitro kinase assay, Hesperadin IC50 = 40 nM) blocked recombinant trypton histone H3 phosphorylation by T. brucei Aurora kinase-1 (TbAUK1) fro the pathogenic Trypanosoma brucei. Hesperadin IC50 = 48 nM) significantly inhibite the growth of cultured infectious blood form (BF) cells, while Hesperadin IC50 = 550 nM) and weakly inhibite the growth of insect circulation stage (PF) cells.
• Cell Research:
  HeLa cells and PtK1 cells are added Hesperadin 500 nM for 24 and 48 hours.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

bloodstream, Autophagy, Aurora, AuroraKinase, Aurora Kinase, Aurora B (human), forms, Inhibitor, Hesperadin, inhibit, InfluenzaVirus, Influenza Virus, Parasite, TbAUK1, procyclic

Compound Identifiers

PubChem CID

135421442