Hernandezine

SKU: orb1297342

Description

Hernandezine is a natural isoquinoline alkaloid that functions as an AMPK activator and reverses ABCB1-mediated multidrug resistance (MDR) in cancer cells. It is utilized in vitro to study MDR reversal mechanisms and AMPK-related pathways in oncology research.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 6681-13-6
• MW: 652.78
• Purity: 99.53% (May vary between batches)
• Formula: C₃₉H₄₄N₂O₇
• SMILES: [H][C@]12Cc3ccc(Oc4cc(C[C@]5([H])N(C)CCc6c(OC)c(OC)c(OC)c(Oc7cc1c(CCN2C)cc7OC)c56)ccc4OC)cc3
• Target: P-gp,AMPK,TNF,ROS

Bioactivity

• In Vitro:
  Hernandezine inhibits LPS-induced TNF-α expression/production in human macrophage cell lines (THP-1 and U93). Hernandezine inhibits the transport function of ABCB1, and enhances drug-induced apoptosis in cancer cells. Hernandezine significantly resensitizes ABCB1-overexpressing cancer cells to multiple chemotherapeutic drugs at nontoxic, nanomolar concentrations.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNF-α, ROS, Pgp, AMPK, ABCB1, Hernandezine

Compound Identifiers

PubChem CID

72343