Heparin sodium salt

SKU: orb1300687

Description

Heparin sodium is a glycosaminoglycan anticoagulant that acts by binding to antithrombin III, potentiating the inhibition of thrombin (Factor IIa) and Factor Xa. It is widely used in biochemical research for anticoagulation in vitro and for studying thrombosis and hemostasis mechanisms in experimental models.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 9041-08-1
• MW: 1157.89
• Formula: C₂₆H₄₂N₂NaO₃₇S₅
• SMILES: [Na+].OCCN1CN(CCO)CN(CC[O-])C1
• Target: Autophagy,Factor Xa,Thrombin
• Solubility: H2O:126.3 mg/mL

Bioactivity

• In Vitro:
  Heparin contains a speci c pentasaccharide sequence that binds and activates the plasma proteinase inhibitor AT, which accounts for most of the increase in inhibitory activity toward Factor Xa induced by heparin. Heparin binds, via the speci c pentasaccharide sequence, to AT is a two-step process, involving formation of an initial complex with a Kd of ～4×10 5M, followed by conformational changes in both the AT and saccharide moieties. Heparin 12-mer binds to FGF2 monomer covalently is able to induce FGFR activation (stimulate mitogenesis). Heparin induces aggregation of platelets in citrated platelet-rich plasma and enhances platelet aggregation and serotonin secretion induced by other agents, and this action of heparin is blocked by substances that elevate platelet cyclic AMP and by EDTA but not by inhibitors of platelet cyclooxygenase. Heparin controls, through a post-translational mechanism, the levels of specific cassettes of positively charged proteases inside mast cells. Heparin activates the inhibition of thrombin by antithrombin by bringing them into close apposition, but there is also a direct activation of inhibition due to an overall conformational change induced by the binding to the core pentasaccharide present in both heparin and heparans.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Heparin sodium, Heparin sodium salt, Factor Xa, FactorXa, Autophagy, Sodium heparinate, Thrombin, Thrombin III

Quick Database Links

Gene Symbol

Autophagy,Factor Xa,Thrombin