HEMTAC CDK4/6 degrader 1

SKU: orb1982395

Description

HEMTAC CDK4/6 degrader 1 is a PROTAC molecule that simultaneously engages HSP90 and CDK4/6, facilitating targeted protein degradation. It induces CDK4/6 degradation in B16F10 melanoma cells, leading to G0/G1 cell cycle arrest and apoptosis, making it a useful research tool for cancer studies.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2821803-61-4
• MW: 953.49
• Formula: C₄₈H₅₃ClN₁₆O₄
• SMILES: O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4CCN(CC(NCC5=CN(CCC#CC=6C=7C(N(CC8=C(C)C(OC)=C(C)C=N8)C6)=NC(N)=NC7Cl)N=N5)=O)CC4)N2)C9CCCC9
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

167312304