Hemicholinium dibromide

SKU: orb1225343

Description

A potent inhibitor of the high affinity uptake system for choline. It has less effect on the low affinity uptake system. Since choline is one of the components of acetylcholine, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.

Key Properties

• CAS Number: 312-45-8
• MW: 574.35
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₄Br₂N₂O₄
• SMILES: OC1(C2=CC=C(C3=CC=C(C4(O)OCC[N+](C)(C)C4)C=C3)C=C2)OCC[N+](C)(C)C1.[Br-].[Br-]
• Target: ChR
• Solubility: DMSO: 10 mM

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: The human small cell lung carcinoma cell line NCI-H69. Concentration: 1 mM. Incubation time: Added every day for 2 days. Result: Markedly inhibited cell viability.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HC3 | HC 3 | HC-3 | Hemicholinium3 | Hemicholinium 3

Quick Database Links

Gene Symbol

ChR