Heclin

SKU: orb1305519

Description

Heclin is a cell-permeable small molecule inhibitor targeting the HECT domain of E3 ubiquitin ligases, including Smurf2, Nedd4, and WWP1, with IC50 values ranging from 6.3 to 6.9 µM. It is a valuable research tool for studying ubiquitination pathways in cellular and biochemical assays, applicable in cancer and developmental biology research.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 890605-54-6
• MW: 283.33
• Purity: >98%
• Formula: C₁₇H₁₇NO₃
• SMILES: CCC1=CC=C(O1)\C=C\C(=O)NC1=CC=C(C=C1)C(C)=O
• Target: Ubiquitin ligase
• Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).

Bioactivity

• Target IC50:
  WWP1:6.9 μM|Nedd4:6.3 μM|SMURF2:6.8 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E1Enzyme, E1/E2/E3 Enzyme, E1 Enzyme, E1 activating enzyme, E2 conjugating enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E3 ligating enzyme, E3Enzyme, inhibit, HECT E3 ubiquitin ligase, Heclin, Inhibitor, Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme

Compound Identifiers

PubChem CID

7464118