Hdm2 E3 ligase inhibitor 1

SKU: orb3134465

Description

Hdm2 E3ligaseinhibitor 1 (Compound 1) is a reversible inhibitor of Hdm2-mediated p53 protein ubiquitination, with an IC50 of 12.7 μM. It binds to Hdm2, blocking the transfer of ubiquitin catalyzed by Hdm2 from pre-linked Ub-Ubc4 to p53, thereby inhibiting p53 ubiquitination, stabilizing p53 protein in tumor cells, and exerting antitumor activity.

Research Area

Cell Biology, Pharmacology & Drug Discovery; Molecular Biology; Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 414905-09-2
• MW: 350.24
• Formula: C₁₀H₈F₆N₂O₃S
• SMILES: O=C(NC1=CC=C(C=C1)S(=O)(=O)N)C(C(F)(F)F)C(F)(F)F
• Target: MDM-2/p53,E1/E2/E3 Enzyme

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MDM-2/p53,E1/E2/E3 Enzyme