HDB-1

SKU: orb3209958

Description

HDB-1 is a selective inhibitor of the P2Y14 receptor (P2Y14R) with an IC50 of 26 pM. HDB-1 shows no significant inhibition on P2Y1R, P2Y2R, P2Y4R, P2Y6R, and P2Y12R. HDB-1 blocks the activation of hepatic stellate cells (HSC) by inhibiting the PKA/Raf1/MEK/ERK signaling pathway mediated by P2Y14R, thereby alleviating the core pathological process of liver fibrosis. HDB-1 is used in liver fibrosis research models to investigate purinergic receptor signaling specificity, hepatic stellate cell activation pathways, and downstream MAPK pathway modulation in fibrogenesis-related cellular systems.

Key Properties

• CAS Number: 3021527-82-9
• MW: 319.31
• Purity: 99.12% (May vary between batches)
• Formula: C₁₈H₁₃N₃O₃
• SMILES: O=C1C(=O)C(NC=2C=CC=3N=COC3C2)=C1NC4=CC=C(C=C4)C
• Target: P2Y Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

P2Y Receptor