HDAC/PSMD14-IN-1

SKU: orb3027966

Description

HDAC/PSMD14-IN-1 is a derivative of gambogic acid. It serves as an orally active dual inhibitor targeting PSMD14 and HDAC1, with IC50 values of 238.7 nM and 141.2 nM, respectively. The compound exhibits significant cytotoxicity against ESCC cell lines (IC50: 30-250 nM) and effectively reverses epithelial-mesenchymal transition (EMT). Additionally, HDAC/PSMD14-IN-1 can induce apoptosis. In KYSE30 cell xenograft models in mice, it displays antitumor activity. HDAC/PSMD14-IN-1 is useful for researching esophageal cancer treatment.

Research Area

Cell Biology, Epigenetics & Chromatin, Epigenetics & Chromatin; Cell Biology, Molecular Biology

Key Properties

• CAS Number: 3062141-62-9
• MW: 432.56
• Formula: C₂₀H₂₄N₄O₃S₂
• SMILES: O=C1C(NC(=O)CCCCCCC(=O)NC=2C=CC=CC2N)=C3SSC=C3N1C
• Target: Apoptosis,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,HDAC