HDACi-4b

SKU: orb1224765

Description

A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells; reverses FXN silencing in primary lymphocytes from individuals with Friedreich's ataxia; directly affects the histones associated with FXN, increasing acetylation at particular lysine residues on histones H3 and H4 (H3K14, H4K5 and H4K12); significantly improves motor performance, overall appearance, and body weight in an HD mouse model.

Key Properties

• CAS Number: 537034-15-4
• MW: 325.4048
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₃N₃O₂
• SMILES: O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O
• Target: HDAC
• Solubility: DMSO: ≥ 29 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NKL22 | NKL-22

Quick Database Links

Gene Symbol

HDAC