HDAC/HSP90-IN-2

SKU: orb3174939

Description

HDAC/HSP90-IN-2 (compound 26) is a potent dual inhibitor of HDAC (IC50= 194 nM) and HSP90 (HSP90α IC50= 153 nM). It induces HSP70 expression, downregulates HSP90 substrate proteins, and promotes the acetylation of α-tubulin and histone H3 in cancer cells. Additionally, HDAC/HSP90-IN-2 reduces PD-L1 expression in H1975 cells treated with IFN-γ and is applicable in the research of cancers such as lung cancer and colon cancer.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2244714-45-0
• MW: 485.58
• Formula: C₂₆H₃₅N₃O₆
• SMILES: O=C(NO)CCCCCCCC(=O)NC1=CC=C(C=C1)N(C(=O)C=2C=C(C(O)=CC2O)C(C)C)C
• Target: PD-1/PD-L1,HDAC,Microtubule Associated,HSP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PD-1/PD-L1,HDAC,Microtubule Associated,HSP