HDAC/HSP90-IN-1

SKU: orb3174827

Description

HDAC/HSP90-IN-1 (compound 20) is a potent dual inhibitor targeting HDAC (IC50 = 194 nM) and HSP90 (HSP90α IC50 = 153 nM). It induces the expression of HSP70, downregulates HSP90 substrate proteins, and enhances the acetylation of α-tubulin and histone H3 in cancer cells. Additionally, HDAC/HSP90-IN-1 reduces PD-L1 expression in IFN-γ-treated H1975 cells. This compound is applicable in research on cancers such as lung and colon cancer.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2244714-37-0
• MW: 471.55
• Formula: C₂₅H₃₃N₃O₆
• SMILES: O=C(NO)CCCCCCC(=O)NC1=CC=C(C=C1)N(C(=O)C=2C=C(C(O)=CC2O)C(C)C)C
• Target: HSP,HDAC,Microtubule Associated,PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HSP,HDAC,Microtubule Associated,PD-1/PD-L1