HDAC8-IN-20a

SKU: orb1703387

Description

HDAC8-IN-20a is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. It blocks growth receptor survival signaling and is a valuable chemical probe for studying HDAC8's role in cancer biology and neuroblastoma in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1884231-52-0
• MW: 273.28
• Purity: 99.01% (May vary between batches)
• Formula: C₁₅H₁₅NO₄
• SMILES: O(CC1=CC=CC=C1)C2=C(OC)C=CC(C(NO)=O)=C2
• Target: HDAC
• Solubility: DMSO:22.5 mg/mL (82.33 mM)

Bioactivity

• Target IC50:
  HDAC8 (human):23.9 μM|smHDAC8:268.2 μM|HDAC1 (human):12.1 μM|HDAC6 (human):2.9 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDAC8, HDAC8 IN 20a, HDAC8 inhibitor 20a, HDAC8 inhibitor-20a, HDAC8IN20a, HDAC-8-IN-20a, HDAC8-IN-20a

Compound Identifiers

PubChem CID

127046854