HDAC8-IN-12

SKU: orb2665248

Description

HDAC8-IN-12 (compound 5k) is a potent and selective non-hydroxamic acid HDAC8 inhibitor (IC50 = 0.12 nM). It demonstrates anti-breast cancer activity in vitro and in an orthotopic mouse model, where it modulates the tumor immune microenvironment by activating T cells and shifting macrophage polarization from M2 to M1.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 3028095-13-5
• MW: 331.32
• Formula: C₁₆H₁₇N₃O₅
• SMILES: O=C(C=CC1=CC=C(C=C1OC)C=C2C(=O)NCC(=O)N2C)NO
• Target: HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176419163