HDAC8-IN-1

SKU: orb1300091

Description

MDK-7933 (HDAC8-IN-1) is a potent and selective HDAC8 inhibitor (IC50 = 27.2 nM). It demonstrates antiproliferative and cytotoxic activity against human lung cancer cell lines, including A549, H1299, and CL1-5, while showing minimal effects on normal IMR-90 cells. This compound is a valuable research tool for studying HDAC8 biology in oncology and cancer cell signaling pathways.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1417997-93-3
• MW: 345.39
• Purity: 99.83% (May vary between batches)
• Formula: C₂₂H₁₉NO₃
• SMILES: COc1ccc(\C=C\C(=O)NO)c(c1)-c1ccc(cc1)-c1ccccc1
• Target: HDAC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.79 mM);DMSO:55 mg/mL (159.24 mM)

Bioactivity

• Target IC50:
  HDAC8:27.2 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDAC8, HDAC8 IN 1, HDAC8IN1, HDAC-8-IN-1, HDAC8-IN-1, HDAC, Inhibitor, Histone deacetylases, inhibit

Compound Identifiers

PubChem CID

70676597