HDAC6-IN-67

SKU: orb3173626

Description

HDAC6-IN-67 is a selective HDAC6 inhibitor with an IC50 of 17.15 nM, demonstrating 19-fold selectivity over HDAC1. It selectively inhibits HDAC6 by interacting with Ser531 and His614. HDAC6-IN-67 induces apoptosis by cleaving caspase9, 8, 3 and PARP, upregulating Bax expression, and downregulating Bcl-2 expression. It effectively acetylates α-tubulin in MCF-7/ADR cells without affecting histone H3 acetylation. HDAC6-IN-67 is applicable in breast cancer research.

Key Properties

• CAS Number: 2196247-20-6
• MW: 309.33
• Formula: C₁₇H₁₅N₃O₃
• SMILES: O=C(NO)C1=CC=C(C=C1)CN2C(=O)C=3C=CC=CC3N=C2C
• Target: HDAC,Microtubule Associated,Bcl-2 Family,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HDAC,Microtubule Associated,Bcl-2 Family,Apoptosis,Caspase