HDAC6-IN-45

SKU: orb3134716

Description

HDAC6-IN-45 (Compound 15) is a selective inhibitor of HDAC6, with an IC50 of 15.2 nM. It exerts neurotrophic effects by upregulating GAP43 and Beta-3 Tubulin markers. Additionally, HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, and inhibits apoptosis in PC12 cells. In zebrafish models of Alzheimer's disease, it demonstrates neuroprotective properties. Moreover, HDAC6-IN-45 exhibits antioxidant activity and has favorable blood-brain barrier (BBB) permeability.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 3048532-05-1
• MW: 393.45
• Formula: C₂₃H₂₄FN₃O₂
• SMILES: O=C(NO)C1=CC=C(C=C1)CN2CC3=C(C=4C=C(F)C=CC4N3CC5CC5)CC2
• Target: HDAC,Reactive Oxygen Species,Apoptosis,Nrf2

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HDAC,Reactive Oxygen Species,Apoptosis,Nrf2