HDAC6-IN-34

SKU: orb2566129

Description

HDAC6-IN-34 (compound 21), an orally active, selective HDAC6 inhibitor, exhibits an IC50 of 18 nM. It enhances tubulin acetylation levels without impacting histone acetylation in cutaneous T-cell lymphoma cells and suppresses TNF-α secretion in LPS-stimulated macrophage cells. Furthermore, HDAC6-IN-34 demonstrates outstanding anti-arthritic efficacy in rats.

Key Properties

• CAS Number: 1432508-73-0
• MW: 381.35
• Formula: C₁₈H₁₈F₃N₃O₃
• SMILES: C(N1C2=C(C(C(F)(F)F)=N1)C(=O)CC(C)(C)C2)C3=CC=C(C(NO)=O)C=C3
• Target: HDAC

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HDAC