HDAC3-IN-6

SKU: orb2944411

Description

HDAC3-IN-6 (SC26) is a potent and selective HDAC3 inhibitor (IC50 = 53 nM). It demonstrates antitumor activity in colorectal cancer models by upregulating PD-L1 expression, inducing apoptosis, and generating reactive oxygen species (ROS) in both cellular and in vivo studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• MW: 417.46
• Formula: C₂₃H₂₃N₅O₃
• SMILES: CCCNNC(=O)C1=CC=C(C=C1)CNC(=O)C2=CN=C(N2)C3=CC4=C(C=C3)OC=C4
• Target: Apoptosis,HDAC,ROS,Reactive Oxygen Species,PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677140